2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-42489
    N3-PEG3-CH2CH2-Boc 252881-73-5 ≥98.0%
    N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2-Boc
  • HY-130488
    Hydroxy-PEG2-C2-PFP ester 1820673-42-4
    Hydroxy-PEG2-C2-PFP ester is a PEG/Alkyl/ether-based?PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-C2-PFP ester
  • HY-W108219
    Benzyl-PEG4-Ots 89346-82-7
    Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG4-Ots
  • HY-140619
    DNP-PEG4-DBCO 2149585-17-9
    DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DNP-PEG4-DBCO
  • HY-130385
    Propargyl-PEG6-NHS ester 2093153-99-0 98.0%
    Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG6-NHS ester
  • HY-W096094
    Fmoc-N-amido-PEG2-alcohol 299430-87-8 99.51%
    Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-amido-PEG2-alcohol
  • HY-140903
    Biotin-PEG4-TFP ester 2985664-57-9 98.21%
    Biotin-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-TFP ester
  • HY-W096166
    Bis-acrylate-PEG6 85136-58-9 98.0%
    Bis-acrylate-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-acrylate-PEG6
  • HY-141375
    m-PEG5-Br 854601-80-2 98.0%
    m-PEG5-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-Br
  • HY-134677
    Bromo-PEG7-Boc 2766000-37-5
    Bromo-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-Boc
  • HY-140931
    Dde Biotin-PEG4-DBCO 1807512-43-1
    Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Dde Biotin-PEG4-DBCO
  • HY-77593
    (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 147266-92-0 ≥98.0%
    N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • HY-138507
    Desthiobiotin-PEG4-acid
    Desthiobiotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Desthiobiotin-PEG4-acid
  • HY-W013522
    Me-PEG4-Me 143-24-8 99.93%
    Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Me-PEG4-Me
  • HY-130232
    Mal-amido-PEG2-TFP ester 1431291-44-9 98.68%
    Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-TFP ester
  • HY-W881439
    1-(1,1-Dimethylethyl) tridecanedioate 2703752-86-5
    1-(1,1-Dimethylethyl) tridecanedioate is a PROTAC Linker and can be used for PROTAC synthesis, such as FF2039 (HY-172159).
    1-(1,1-Dimethylethyl) tridecanedioate
  • HY-150311
    endo-BCN-PEG24-NHS ester
    endo-BCN-PEG24-NHS ester is composed of a benzocyclonorbornene, a twenty-tetramer of polyethylene glycol (PEG) and an N-hydroxysuccinimide ester. endo-BCN-PEG24-NHS is utilized as linker for synthesis of PROTAC molecule.
    endo-BCN-PEG24-NHS ester
  • HY-130376
    Propargyl-PEG8-NHS ester 2182601-74-5
    Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-NHS ester
  • HY-130477
    Fmoc-Lys (biotin-PEG4)-OH 1334172-64-3
    Fmoc-Lys (biotin-PEG4)-OH is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys (biotin-PEG4)-OH
  • HY-W075674
    Butane-1,4-diyldiphosphonic acid 4671-77-6
    Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Butane-1,4-diyldiphosphonic acid
PROTAC Linkers Isoform Comparison

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